Effect of Weile-Decoction on Chronic Atrophic Gastritis in Rats

OBJECTIVE To observe the effect of Weile-Decoction on chronic atrophic gastritis(CAG) in rats of the number of gastric glands, the glands thickness, the number of primary cells and parietal cells, the indicators of gastric inflammation and gastrin in serum. METHODS An experimental CAG model was established by comprehensive factors, including using active immunization, alternative ingestion with sodium deoxycholate and 30%-60% alcohol. Then CAG rats were randomly divided into 5 groups: the high dosage group of Weile-Decoction(10.60g·kg^-1); medium dosage group of Weile-Decoction(5.30 g·kg^-1); low dosage group of Weile-Decoction(2.65 g·kg^-1); Yangweishu Keli(4.0 g·kg^-1) positive control group and model control group(saline 10 mL·kg^-1). Nomal healthy Wistar rats were also used as normal control group. After consecutive treatment for 6 weeks, gastrin content in serum and inflammatory reaction, the thickness and the number of gastric glands, the number of parietal cells and chief cells in gastric mucosa were observed. RESULTS Weile-Decoction can significantly increase the body weight(P<0.05-0.01), the number of gastric glands, the glands thickness, the number of primary cells and parietal cells(P<0.05-0.001), and also significantly reduced the indicators of gastric inflammation(P<0.001) for CAG in rats. Weile-Decoction can significantly increase gastrin in serum. CONCLUSION Weile-Decoction can significantly improve the gastric tissue for CAG in rats.