Study of Prevent Vomiting and Esophageal Epithelial Hyperplasia Inhibition Effect of Shu Er Tong He Ji

OBJECTIVE To observe the role of the Shu Er Tong He Ji in preventing vomiting and inhibiting of esophageal epithelial hyperplasia. METHODS Vomiting animal model was established by CuSO4 intraveneus injection in pigeon. The vomiting precent role was observed by drip delivery of Shu Er Tong He Ji. Rats esophaged reflux model was produced by operation. The influence of drug on epithelial tissue hyperplasia was observed by drip irrigation. RESULTS The Shu Er Tong He Ji could relieve the vomit caused by CuSO4, it has significant difference compared with control group on the frequency of vomiting and vomiting latent time (P<0.01); Hematoxylin eosin(HE) staining showed that The Shu Er Tong He Ji can reduce the epithelial damage cause by esophageal reflux. CONCLUSION The Shu Er Tong He Ji might prevent vomiting and improve the esophageal epithelium due to tissue damage caused by the reflux.