Effect of Jianpi Xiaozhang Tablets on Content of Rat Gastric Acid, Pepsin Activity and Gastrointestinal Electrical Activity

OBJECTIVE Study effects of Jianpi Xiaozhang tablets on content of gastric acid, pepsin activity and gastric electrical activity in rats. METHODS Ligation pyloric and duodenal junction of rats, measuring content of rat gastric acid and pepsin activity; Record 5 min electrogastrogram with EGEG-8D gastrointestinal electrical instrument, measuring frequency and amplitude to observate the impact of Jianpi Xiaozhang tablet on rat antral electrical activity, electrical activity of small intestine. RESULTS The groups of medium and high doses of Jianpi Xiaozhang tablets could make the rat gastric acid content increased significantly, the group of high dose of Jianpi Xiaozhang tablets made the pepsin activity in rats significantly increased, the groups of medium and high doses of Jianpi Xiaozhang tablets could make the pepsin activity in rats significantly elevated. The groups of medium and high doses of Jianpi Xiaozhang tablets made rat antral electrical activity frequency increased significantly. The group of low dose of Jianpi Xiaozhang tablets could make the rat antral electrical activity significantly elevated. The groups of low, medium and high doses of Jianpi Xiaozhang tablets could make the rat antral electrical activity significantly higher in large amplitude. The groups of low, medium and high doses of Jianpi Xiaozhang tablets made frequency and amplitude of the rat small intestinal electric activity significantly elevated. CONCLUSION Jianpi Xiaozhang tablets have clinical significance to promote digestion.