Analysis of Literature on Adverse Drug Reactions of Sorafenib

OBJECTIVE To investigate the characteristics and regularity of ADR induced by sorafenib. METHODS The case reports of soeafenib ADR which were published at international medical academic periodicals during 2006-2011 were collected and analyzed statistically in respect of gender, age, case history, dosage, clinical manifestation and results of treatment. RESULTS A total of 86 adverse reactions were identified and included in the analysis, 28 cases were unexpected ADR, 34 cases of serious ADR and 20 cases of unexpected serious ADR. Lesion of skin and its appendants were the most commonly reported ADR(n=36, 41.86%), followed by lesion of endocrine system(n=18, 20.93%); unexpected and/or serious ADR were reported more frequently in digestive system (n=11, 12.79%, 5 death), followed by multiple organ response (n=10, 11.63%) CONCLUSION Sorafenib is associated with a significant risk of various ADR in body. In order to reduce the incidence of ADR, careful clinical observation is necessary.