Observations of Application of Three Different Medicine during Withdrawal in Patients with Spinal Operation

OBJECTIVE To observe the effects of sufentanil, sufentanil combined with flurbiprofen and pentazocine during withdrawal in patients with spinal operation. METHODS Sixty patients underwent spinal operation were randomly divided into sufentanil group, sufentanil combined with flurbiprofen group and pentazocine group. There were twenty patients in each group. The same general anesthesia was done to every patient. Sufentanil, sufentanil combined with flurbiprofen and pentazocine was injected to every patient by vein before 25 minutes at the end of surgery. The mean arterial blood pressure(MAP), heart rate(HR), arterial oxygen saturation(SpO2), spontaneously breathing recovery time, extubation, respiratory depression, post-operation restlessness and VAS was recorded at specified time point. RESULTS There were no significant difference of spontaneously breathing recovery time, post-operation restlessness and VAS in the 3 groups. The recovery and extubation time was longer and the incidence rate of respiratory depression was higher in S group than P group and SF group (P<0.05). CONCLUSION Three groups of the preparation method with the medicine have more inhibitory effects on cardiovascular effects, ease the post-operation pain and reduce the incidence rate of restlessness. The sufentanil can lengthen the spontaneously breathing recovery time and extubation time.