Comparative Study of Olanzapine Combined with Shuxuening Versus Olanzapine in the Treatment of Chronic Schizophrenia Patients

OBJECTIVE To compare the efficacy and safety of olanzapine combined with Shuxuening versus olanzapine in the treatment of chronic schizophrenia inpatients. METHODS Eighty-six patients were recruited in our hospital and randomly assigned to receive olanzapine combined with Shuxuening, or olanzapine for up to 12 weeks. All patients were checked by the scale of PANSS and TESS before treatment and at 4, 8 and 12 weeks during treatment. RESULTS There were statistically significant differences between the trial group and the control group in efficacy and adverse reactions(P<0.05). The effective rate of the research group was 34.88%, the control group was 20.93%. The incidence rates of adverse reactions in research group were lower than those in control group in dizziness, drowsiness, tachycardia and weight gain. CONCLUSION Olanzapine combined with Shuxuening may be more efficacious than olanzapine lonely in the treatment of chronic schizophrenia patients, and be much lower in adverse reactions.