Investigation on Modulation of Human Cytochrome P450 and P-glycoprotein by Herb or Natural Product Using in vivo Probe Substrate

OBJECTIVE To promote the in vivo investigation on modulation of human cytochrome P450and P-glycoprotein by herb or natural product, anticipate clinical drug interaction and improve rational drug use. METHODS Literatures using in vivo probe substrate were reviewed. RESULTS Research in this respect abroad is hot. Cocktail methods are widely used. CONCLISIONS In vivo probe substrate phenotying studies should be paid more attention in investigation on modulation of CYP and P-gp by herb and natural products.