Study on the Extraction of Dictamni Cortex with Ultrasonic Wave Technology Optimized by Central Composite Design and Response Surface Method

OBJECTIVE To optimize the extracting process of Dictamni Cortex by central composite design and response surface method. METHODS Independent variables were ethanol concentration, time for ultrasound extraction and solvents ratio, dependent variables were the overall desirability of the extraction rate of dictamnine and the extract yields. Linear or nonlinear mathematic models were used to estimate the relationship between independent and dependent variables. Response surface methodology was used to optimize the process of extraction. RESULTS The optimal conditions of extraction process were determined as follows: the materia medica was ultrasound extracted for 80-90 min with 15-20 fold solvent of 85%-95% ethanol. CONCLUSION The optimum process is simple and convenient for extracting Dictamni Cortex. The observed values are consistent with the predicted ones.