Determination of Residual Dichloromethan in Fluoxetine by GC

OBJECTIVE To detect the residue dichloromethane in fluoxetine by gas chromatography(GC). METHODS Residue dichloromethane in fluoxetine was detected by GC with DB-624 column(30 m×0.53 mm), ECD detector and nitrogen as carrier gas(0.05 MPa). Injector and detector temperatures was set at 150 and 300 ℃ respectively. Column temperature was programmed set. Injection volume was 1 μL and the split ratio was 1∶20. RESULTS Dichloromethane showed a good linear relationship in the range of 5.96~71.55 μg·mL^-1(r=0.999 6), the residue dichloromethane in three batches of samples coincided with the requirements(<0.06%). CONCLUSION Gas chromatography(GC) is simple, accurate, sensitive. It can be used for the determination of dichloromethane in fluoxetine.