Observation on the Influence of Shenqifuzheng Injection on Immune Function and the Quality of Life of the Patients with StageⅡ/Ⅲ Colorectal Cancer with Chemotherapy

OBJECTIVE To explore the immune function and the influence on the quality of life of Shenqifuzheng injection to stage Ⅱ/Ⅲ colorectal cancer patients combined with chemotherapy. METHODS Eighty-nine patients with stage Ⅱ/Ⅲ colorectal cancer were randomly divided into the chemotherapy group and combined treatment group. The chemotherapy group accepted FOLFOX4 chemotherapy and combination therapy group were treated with FOLFOX4 chemotherapy plus Shenqifuzheng injection. Karnofsky score was recorded, cellular immune function index (detection CD₃⁺, CD₄⁺, CD₈⁺ T cells and NK cells (CD₁₆⁺, CD₅₆⁺) and the percentage of CD₄⁺/CD₈⁺ ratio, IgG, IgA and IgM) and chemotherapy adverse reaction was observed. RESULTS Karnofsky score displayed that combined treatment group had better curative effect than the chemotherapy group(P<0.01). After seven days of treatment, CD₃⁺, CD₄⁺, CD₄⁺/CD₈⁺, NK, IgG, IgA and IgM in the combination group were higher than the chemotherapy group(P<0.05), CD₈⁺ had no obvious difference. The immunoglobulin in combination group was significantly higher than the chemotherapy group. The adverse reaction of chemotherapy in combination group was less and relatively lighter, which were mainly Ⅰ-Ⅱ level. The adverse reaction of the two groups had significant difference (P<0.05). CONCLUSION Shenqifuzheng injection can reduce adverse reaction of chemotherapy with FOLFOX4 with Ⅱ/Ⅲ stage colorectal carcinoma, improve the body function and improve their cellular immune function, thus improving patients on chemotherapy adherence to chemotherapy, the coordination function, to improve prognosis in patients with colorectal cancer, improve the quality of life, and has a good clinical value.