Dry Granulating Technique Research of Zaorenshen’an Tablet by Orthogonal Experiment

OBJECTIVE To optimize conditions and parameters of Zaorenshen’an tablet, which was prepared by dry granulating technique. METHODS Taking granule yield and granule friability as measure indexes, the L9(34) orthogonal experiment was used to study the best conditions and parameters of dry granulating technique of Zaorenshen’an tablet. The factors, including roller pressure, roller speed, moisture content of power and transfer speed were studied in the experiment. RESULTS The optimal technique was: roller pressure at 1.5 MPa, roller speed at 12 r·min^-1, moisture content of power under 6%, transfer speed of mixture of drug and accessories at 50 r·min^-1. CONCLUSION The process of dry granulating technique of Zaorenshen’an tablet is stable and reliable, which can be used for industrial production.