Quality Evaluation of Quercrtin Proliposomes

OBJECTIVE To prepare liquid quercetin proliposomes and investigate their pharmaceutical characteristics in vitro. METHODS A new kind of proliposome preparation method was used to prepare quercetin liquid proliposomes. The liposome membrane material and drug was dissolved in the dispersion medium according to a certain proportion, forming an anhydrous transparent solution and then the properties of the liposomes including the shape, the size, the zeta potential, the entrapment efficiency and the self-assemble rate in vitro were studied after the proliposomes were changed into the liposomes. Furthermore, the in vitro release of quercetin from proliposmes was investigated. RESULTS Quercetin oral proliposomes could self-assemble into nanoscale liposome suspension rapidly in water. Liposomes showed spherical morphology. The average size of particle was 228.7 nm and the Zeta potential was -21.2 mV. The entrapment efficiency was up to 90%. The in vitro release could be characterized by Higuchi equation. CONCLUSION The method for quercetin oral proliposomes preparation is simple and feasible. The entrapment efficiency of proliposome is high with good stability and the drug can be sustained released from the liposomes.