Analysis of Thirty-two Liver Injury Cases Induced by Ciprofloxacin

OBJECTIVE To investigate the characteristics and regularities of liver injury induced by ciprofloxacin, and provide a reference for clinicians in rational drug use. METHODS To retrieve the related medicine databases from domestic and abroad, and download the case reports and analyze them. RESULTS There were 32 cases of liver injury induced by ciprofloxacin in which 22 cases were male, 23 cases were more than 40 years-old. The main clinical manifestations of liver injury induced by ciprofloxacin were jaundice, nausea, abdominal pain, elevated transaminases. The main types of liver injury were hepatocellular type and cholestatic type. Mixed type was rare. The high-risk groups and high-risk factors were older, male, drug allergy history, primary liver disease, combined application of the drugs with liver toxicity, the causative drugs again, excessive dosage of drugs, too long course of treatment. The most cases returned to normal after drug withdrawal and corresponding treatments. The liver injury could progress to chronic and liver failure, even death. There were at least three death cases. CONCLUSION The liver injury induced by ciprofloxacin is a serious adverse drug reaction, and should be paid attention for the clinicians.