Determination of Tetrachloromethane in Letrozol by Headspace Analysis with μ-ECD

OBJECTIVE To establish a method for the quantitative determination of tetrachloromethane in Letrozol by GC. METHODS Tetrachloromethane was analyzed by Gas Chromatography with SE-30 column, μ-ECD detector, and programming temperature from 50 ℃ to 150 ℃. RESULTS Experimental results showed that a good separation of tetrachloromethane with other contents of sample was achieved on SE-30 column, and the separation degree was more than 2.0. The calibration curves of solvent was linear in 0.000 516-0.020 64 μg·mL^-1. The limit of detection was 0.01 μg·g^-1. CONCLUSION This method is simple, rapid, accurate and precise, and can be used for the quality control of residual tetrachloromethane in Letrozol.