Optimization of Transdermal Penetration Enhancer for Buspirone Hydrochloride and Study on in Vitro Permeation Mechanism

OBJECTIVE To study the effect of penetration enhancers for buspirone hydrochloride on drug permeation of rats skin in vitro and the percutaneous mechanism of buspirone hydrochloride. METHODS The Franz diffusion chamber was applied for evaluating the different kinds, concentration and proportion of penetration enhancer on the buspirone hydrochloride permeability in vitro. By inspecting the effect of medium pH and skin condition on the permeation to study the percutaneous mechanism. RESULTS It was discovered that drug had favorable permeation with 3% Azone as the enhancer of buspirone hydrochloride. With increase of molecular pattern concentration, the steady permeation speed of buspirone hydrochloride was elevated. The barrier effect of stripped stratum corneum was less than that of whole skin, and the deposit function of whole skin was more significant than that of stripped stratum corneum skin. CONCLUSION The effect of promoting penetration of 3% Azone is the best, the drug permeates easily with molecular pattern. Stratum corneum is the leading barrier and reservoir site when medicine is permeating through the skin.