Preparation and Evaluation of Aciclovir Thermosensitive Gel

OBJECTIVE To prepare and evaluate Aciclovir Thermosensitive Gel (ACV-TG). METHODS Poloxamer 407 was selected to prepare ACV-TG. Tube-inversion method was carried out to investigate phase transition behavior. UV method was employed to determine drug content. Franz diffusion cell was used to investigate drug release property. Rabbits were used to evaluate the gelation effect and skin stimulus. RESULTS The prepared ACV-TG was uniform and transparent, with a content of (2.86±0.02)%. The gelation course was reversible at a temperature about 27 ℃. It was sustained released in vitro, fitted by first-order equation. Fine dispersion and no skin stimulus were observed, while the drug retention was five times more than that of solution. And the gelation time was (10±1) s. CONCLUSION ACV-TG was successfully prepared and the properties were qualified.