Preparation and in Vitro Release of Doxorubicin Loaded Mesoporous Silica Nanoparticles

OBJECTIVE To prepare doxorubicin-loaded mesoporous silica nanoparticles and evaluate its release characteristics in vitro. METHODS Mesoporous silica nanoparticles were achieved by condensation methods. The morphology was examined by transmission electron microscope and dynamic light scattering particle size analyzer. Doxorubicin loaded mesoporous silica nanoparticles were achieved by stirring. The encapsulation efficiency, drug loading rate and in vitro cumulative release were evaluated by UV spectrophotometry. RESULTS Distribution of nanoparticles was uniform. The average particle size was about 70 nm (PDI<0.1). The drug loading rate and encapsulation efficiency were (20.38±3.58)% and (55.29±5.17)%. The delivery system reached release equilibrium after shaking in water bath for 24 h. The cumulative release proportion was above 95% in PBS(pH 5.5). CONCLUSION Mesoporous silica nanoparticles with high drug encapsulation efficiency can be used as the carrier of anticancer drug doxorubicin.