Research in Acute Hypersensitive Reaction Caused by Xuesaitong Injection

OBJECTIVE To study the mechanism of acute hypersensitive reaction caused by Xuesaitong injection. METHODS Contents of IgE and histamine in blood serum of guinea-pig and mouse were determined by kits of ELISA. Anaphylactic behaviors of guinea-pig and mouse were observed after administration. Degranulation of mast cell caused by Xuesaitong injection was observed. RESULTS Contents of IgE and histamine were obviously increased after administration. Manifestations of anaphylactic behaviors of mouse were more obvious. And degranulation of mast cell was observed. CONCLUSION Anaphylaxis and anaphylactoid reaction were the main acute hypersensitive reaction caused by Xuesaitong injection. Guinea-pig was not the experimental animal suitable for assay the anaphylactoid reaction caused by injection.