Quality Determination of Salvia Miltiorrhiza in Pharmaceutical Industry By Near-infrared Spectroscopy

OBJECTIVE To rapidly determine the content of tanshinoneⅡA in Salvia miltiorrhiza extraction by near-infrared spectroscopy. METHODS The calibration model of the content of tanshinoneⅡA in Salvia miltiorrhiza and the near infrared spectroscopy of Salvia miltiorrhiza was built with partial least squares. RESULTS The correlation coefficient of calibration (R²) was 0.996 94. Root mean square error of cross validation (RMSECV) was 0.011 8, and external prediction deviation RMSEP of 11 samples was 0.023 7. Predicted average relative error was 1.712 9%. CONCLUSION It is feasible to determine the tanshinoneⅡA content in Salvia miltiorrh. Near-infrared spectroscopy is fast, accurate, simple and nondestructive which can be applied in rapid analysis of large numbers of samples.