Retrospective Analysis on Results of Serum Oxcarbazepine Active Metabolite Concentration Monitoring on Children with Epilepsy

OBJECTIVE To investigate the correlations of oxcarbazepine active metabolite (10-hydroxycarbazepine, MHD) serum concentration in epileptic children with clinical therapeutic effect, dosage, drugs combination, sex, age and body weight. METHODS 310 monitoring records of serum MHD concentration in children with epilepsy were researched retrospectively and data as concentrations, sex, age etc were put into data base, which were analyzed and treated by SPSS (13.0) software. RESULTS A wide range of MHD serum concentrations was observed to be clinically effective in seizure treatment on children with epilepsy. And the serum MHD concentrations were closely correlated with dosages, gender, age, and body weight of patients. CONCLUSION The individual difference in the metabolic processes of oxcarbazepine within individual patient was obvious, so it’s necessary to make individualized remedy according to patients’ specific condition and monitoring result.