Determination of Bisphenol A in Infusion Used Combined Cover and Bisphenol A Migration into Infusion by HPLC

OBJECTIVE To develop a method for determination of bisphenol A in Infusion Used Combined Cover and bisphenol A migration into infusion by HPLC. METHODS A Diamosil-C₁₈ column(4.6 mm×250 mm, 5 μm) and a DAD detector was adopted with methanol and water(80∶20) as mobile phase. The wavelength was 227 nm, the flow rate was 1.0 mL·min^-1. RESULTS The method had a linear range in 1.354-27.08 ng (r=0.999 9). The average recovery of bisphenol A and bisphenol A migration was 91.7%(RSD=2.3%) and 93.9%(RSD=1.8%), respectively. CONCLUSION This method is accurate, sensitive, simple, and can be used for determination of bisphenol A and bisphenol A migration into infusion from Infusion Used Combined Cover.