Study on the Correlation between Dissolution in Vitro and Absorption in Vivo of Lansoprazole Enteric-coated Tablets

OBJECTIVE To investigate the dissolution rate in vivo and bioavailability in beagle dogs of lansoprazole enteric-coated tablets, and to evaluate the correlations of the dissolution in vitro and absorption in vivo. METHODS The drug dissolution in vitro was measured by UV spectrophotometer. The plasma concentration in beagle dogs was measured by HPLC. The correlation of dissolution in vitro and bioavailability in vivo was studied by the Wagnner-Nelson method. RESULTS The relationship between the dissolution fraction ft and the absorption fraction fa was fa=0.8122ft-9.874 6, r=0.956 8. CONCLUSION The correlation between dissolution in vitro and absorption in vivo of lansoprazole enteric-coated tablets was good.