Determination of the Content of Miglitol Tablets by HPLC

OBJECTIVE To establish an HPLC method for content determination of miglitol tablets. METHODS Zorbax TMS(250 mm×4.6 mm, 5 μm) column was used with a mobile phase of phosphate buffer solution(potassium dihydrogen orthophosphate 1.36 g and 1-decanesulfonic acid sodium salt 2.62 g dissolved in water and diluted to 1 000 mL, adjusted to pH 5.5 by 10% phosphoric acid or 10% potassium hydroxide)-acetonitrile(85∶15) and detection wavelength was set at 210 nm. RESULTS The calibration curve of content was linear in the range of 20-500 μg·mL^-1 (r=0.999 9, n=6). The average recovery was 100.8% with RSD of 1.7%. CONCLUSION The method is simple, rapid, sensitive and accurate, and its result of determination is satisfactory. The method can be used for the determination of miglitol tablets.