Study the Allergy of Substrate Materials in TCM Adhesive Plasters

OBJECTIVE To investigate the potential allergy of substrate materials in TCM adhesive plasters and provide the basis safety evaluation of adjuvant materials in TCM adhesive plasters. METHODS Establish mice model of allergy contact dermatitis, detect each substrate materials for mice auricular swelling effect, adopt ELISA test to detect the content of IL-4, IFN-γ, sIL-2R. By comparing the ears thickness, weight, cytokines in adjuvant material groups, blank group, positive control group and different blank matrix groups, the potential allergy of adjuvant material in TCM adhesive plasters was investigated. RESULTS The ears thickness, weight, cytokines from positive control group, rubber group, rosin group were all different from blank group, but there was no significant differences in Zinc oxide, TiO₂ and lanolin group. CONCLUSION The allergy of rubber and rosin are higher than zinc oxide, TiO₂ and lanolin.