Analysis of 325 Cases on Drug-Induced Hepatic Injury

OBJECTIVE To analyze the characteristics of drug-induced hepatic injury for providing some clinical reference. METHODS All of 325 cases over a 10-year period in our hospital were analyzed retrospectively. RESULTS In 325 cases, there were 164 males and 161 females, with a mean age of 47.2±17.0 years. One hundred and fifty six kinds of drugs were involved, included mainly antibacterial drugs(23.4%), traditional chinese medicines(15.1%), hormones and other related substances(13.2%). Classification of drug-induced hepatic injury was made: hepatocellular injury 241 cases, cholestatic injury 50 cases and mixed type injury 26 cases. CONCLUSION Drug-induced hepatic injury mainly included anti-tuberculosis drugs, antithyroid drugs and immunosuppressants. The characteristic included that hepatic injury were occult onset partly, clinical symptoms were serious and they can cure or improve if they were treated timely. It is important to attach importance to drug-induced hepatic injury.