Clinical Research of Applies Imipenem Reasonably Based on Monte Carlo in the Simulation

OBJECTIVE Discusses under the different condition to use Monte Carlo the Simulation result to apply imipenem the treatment result. METHODS Chooses 367 infection patients, before the treatment carries on APACHE to the patientⅡGrading, <20 patient lengthens for the medicine time group 73 examples, the convention for the medicine group 70 examples, ≥20 patient lengthens for the medicine time group 114 examples, the convention gives the medicine group 110 examples, The extension refers to Monte Carlo for the medicine time group the Simulation result, and gives imipenem 0.5 g, q6h to lengthen the total infusion time to 3 h, the convention gives for the medicine group imipenem 0.5 g, q6h, each time infusion time 30 min.Two groups both give the correlation the high-level life function support and the nutrition support, other assistances treat same. RESULTS APACHEⅡGrades <20 to divide the patient to use imipenem to lengthen for the medicine time and the convention gives the formula law curative effect, the prognosis, in hospital time non-statistics difference; But APACHEⅡA grading ≥20 minute patient uses imipenem to lengthen for the medicine time for the formula law in the curative effect, the prognosis, in hospital time all surpasses the convention to the formula law. CONCLUSION Lengthens the imipenem drop note time in the seriously injured infection situation to be possible to cause the patient for the formula law to obtain a bigger profit, this also for reasonably provides the basis using imipenem.