Comparison of the Dissolution Rate of Telmisartan Formulation in Vitro

OBJECTIVE To contrast the in vitro dissolution rate of telmisartan formations in different dissolution medium. METHODS The dissolution rate was revealed according to Ch.P (2010) by UV spectromphotometry, use 1 000 mL solution with different dissolution medium, at the speed of 50 r·min^-1, with (37±0.5)℃．RESULTS In the phosphate saline buffer solution, the dissolution rate of 30 min of all of the formations showed advantage than 85% of labelled amount. However in the 0.1 mol·L^-1 HCl dissolution solution, the dissolution rate of C and D in 60 min was lower than 30% of that. And the dissolution rate of D in 30 min was lower than 10% of that. CONCLUSION It is necessary to control the dissolution rate of telmisartan formulation．