Recent Advances and Application of Pharmacokinetic-pharmacodynamic (PK-PD) Modeling

OBJECTIVE To review the advances on pharmacokinetic-pharmacodynamic (PK-PD) modeling. METHODS On the basis of analysing and concluding the relevant articles for the last ten years, the types, programs and application of PK-PD modeling were summarized. RESULTS There are four kinds of pharmacokinetic-pharmacodynamic (PK-PD) modeling, which were widely applied on drug development, individual administration and clinical detection, providing useful information to guide clinical medication. CONCLUSION PK-PD modeling has been improved and plays important role in drug development with its deep study.