Determination of Residual Organic Solvents in Amoxicillin Sodium for Injection by GC

OBJECTIVE To establish a method for determination of residual organic solvents in amoxicillin sodium for injection. METHODS A DB-624 capillary column(30 m×0.25 mm, 1.4 μm) was used at 40 ℃, the headspace temperature was 85 ℃ and kept for 30 minutes, the temperature of inlets and FID detector were 200 ℃ and 250 ℃, propanol as internal standard, high purity nitrogen as the carry gas. RESULTS Seven residual organic solvents were completely separated and there were good linearies(r=0.999 0-0.999 8). The average recovery rate was in the range of 91.3%-105.7%. CONCLUSION The method proved to be sensitive, simple and accurate, and can be used for determination of residual organic solvents in amoxicillin sodium for injection.