Advances in Peptide-Modified Liposome Targeted Drug Delivery System

OBJECTIVE To introduce the advances of peptide-modified liposome targeted drug delivery system. METHODS The relevant literatures in recent years were referred and summarized. RESULTS The advances of liposomes modified by arginine-glycine-aspartic (RGD) peptide, alanine-proline-arginine-proline-glycine (APRPG) peptide, cell-penetrating peptide (CPP), vasoactive intestinal peptide (VIP) were elaborated. Peptide-modified drug-loaded liposomes may increase the selectivity of drugs in vivo and reduce side effects of drugs to improve their therapeutic index. CONCLUSION Peptide molecules are a class of important bioactive substances to the body, which are applied in targeted drug delivery system by specific-combination of ligand-receptor with good values and application prospects.