Study the Drug Dissolution of Cefadroxil from Different Preparation by Process Analysis

OBJECTIVE To establish a method which can on-line monitor the dissolution of cefadroxil granules. Compare the drug dissolution behavior of different cefadroxil preparation. METHODS Control article method was applied in the study. Monitor the dissolution of cefadroxil from three different preparation by fiber-optic dissolution test system. Compare the characteristics of drug release from three different preparations by dissolution curves. RESULTS The release characteristics of cefadroxil granules can be presented through this method. There is different feature from three different preparations. CONCLUSION An in-situ, real time, on-line and process analysis of dissolution of drug can be obtained by fiber-optic dissolution test system automatically. The release characteristics of different preparation can be presented through dissolution curves directly. An overall assessment of internal quality and clinical medication can be provided.