Effect of Rosuvastatin with Different Doses on C-Reactive Protein and Blood-Fat in Patients Suffered from Coronary Artery Disease and Hypercholesteremia

To investigate the level of high sensitivity C-reactive protein(HS-CRP) and blood-fat in patients suffered coronary artery disease with hypercholesteremia and the effect of rosuvastatin with different doses on it. METHODS Sixty patients with CAD and HC were assigned into common dose group(10 mg·d^-1, C group) and high dose group(40 mg·d^-1, H group), everyone was detected the level of HS-CRP and TC, TG, LDL, HDL before and 1 month after treated with rosuvastatin. RESULTS The level of CRP, LDL-C, TC was much reduced in both the two groups after therapy (P<0.05), while that of H group was even lower than C group (P<0.05). The change of CRP and LDL-C, TC showed a significant correlation (P<0.01). CONCLUSION Rosuvastatin can reduce the level of CRP and LDL, TC obviously. Besides, the effect showed a dose dependent.