Study on Hypoglycemic Effect of Erjing Pill Polysaccharide on Diabetes Rats

OBJECTIVE To observe the hypoglycemic effect of Erjing pill polysaccharide(EPP) on diabetic rats and discuss the mechanism. METHODS The diabetes mellitus(DM) rat model was established by feeding high-energy forage combined with the injection of small-dose of streptozotocin(STZ). According to blood glucose, the rats were divided into model group, low-dose EPP group, mid-dose EPP group, high-dose EPP group. Meanwhile, there were normal group and pioglitazone hydrochloride tablets (PHT) group. The changes of the levels of blood glucose, hemoglobin-A1c, insulin, total cholesterol, triglycerides, high density lipoprotein, low density lipoprotein were observed to study the effect and the mechanism on hypoglycemic effect of EPP. RESULTS Compared with model group, EPP groups significantly decreased fasting blood glucose, hemoglobin-A1c, total cholesterol, triglycerides, low density lipoprotein, and increased insulin and high density lipoprotein. CONCLUSION EPP has obvious effect of decreasing plasma glucose levels on DM rats. The mechanism may be related with an increasing in serum insulin.