Electrocatalytic Reduction of Tinidazole at Room Temperature Ionic Liquid-Multi-Wall Carbon Nanotubes Modified Electrode and Its Electrochemcal Determination

OBJECTIVE Electrochemical behaviors, electrochemical kinetics and electrochemical quantitative determination of tinidazole (TNZ) at glassy carbon electrode (GCE) and room temperature ionic liquid-multi-wall carbon nanotubes modified glassy carbon electrode (RTIL-MWCNTs/GCE) were investigated. METHODS Cyclic voltammetry (CV), chronocoulometry (CC), chronoamperometry (CA), square wave voltammetry (SWV), amperometric I-t curve and alternating current-inpedance (AC-inpedance). RESULTS The reduction peak current of TNZ increased at RTIL-MWCNTs/GCE in comparison with that at the bare GCE and MWCNTs/GCE. At RTIL-MWCNTs/GCE, the reduction peak current was proportional to TNZ concentration over the range of 5.0×10^-5-1.0×10^-2 mol·L^-1. The detection limit was 2.4×10^-6 mol·L^-1. The relative standard deviation was between 0.64%-1.65% and the recoverage was in the range of 98.7%-100.2%. CONCLUSION RTIL- MWCNTs/GCE could catalyze TNZ electrochemical reduction very well, and it was a diffusion-limited electrochemical process. The proposed method could be applied in the electrochemical determination of TNZ content in injection samples with the satisfied results.