Study on Taste-Masking Inclusion Compound of Dextromethorphan

OBJECTIVE To prepare the inclusion compound of dextromethorphan hydrobromide (DH)-β-cyclodextrin (β-CD) and investigate its properties. METHODS The inclusion complex was prepared by grinding method and confirmed by microscope observation, change of differential scanning calorimetry, solubility test and computer simulation methods. The drug loading and the entrapment efficiency were determined by ultraviolet spectrophotometry. RESULTS The inclusion complexes consisted of β-CD and DH at a molar ratio of 1∶3. The drug loading and the entrapment efficiency were determined as 9.83％ and 92.10%, respectively. CONCLUSION The inclusion complexes with high drug loading and entrapment efficiency could be formed at a molar ratio of 1∶3 of DH and β-CD.