Synthesis of Antitumor Agent NSC-639829

OBJECTIVE To synthesize antitumor agent NSC-639829. METHODS NSC-639829 was prepared from 4-amino-2-methylphenol via nucleophilic substitution, isocyanation, and condensation. RESULTS The total yield of NSC-639829 was amount to 40.2% with the purity of 99.5% by HPLC, and its structure was confirmed by MS, 1H-NMR, and elemental analysis. CONCLUSION The synthetic route for NSC-639829 was convenient for industrial manufacture.