The Research Progress on Pyrazinamide

OBJECTIVE To review the progress of pyrazinamide. METHODS This paper provides an overview about the chemical synthesis and biotransformation preparation of pyrazinamide, the advantages of the two methods and the application of pyrazinamide. RESULTS Compared with the chemical method, the microbial preparation of pyrazinamide with the substrate of 2-cyanopyrazine has the more advantages on the friendly reaction conditions, the high output and the purity. CONCLUSION Pyrazinamide is an important anti-tuberculous agent. It is receiving considerable attention for its application in pharmaceutical and chemical industry.