Effects of Blood Glucose, Lipid and Dielectric on SMZCo Pharmacokinetics After Short- and Long-time Exposure to High-altitude

OBJECTIVE To study the effects of blood glucose, lipid and dielectric on SMZCo pharmacokinetics after short- and long-time exposure to high altitude. METHODS The young volunteers of healthy male Chinese Hans were divided into three groups: the plain group, the rapid ascent group and the adaptation group. All subjects in this study were treated with a single dose of SMZCo tablets, and their plasma concentration of SMZ were determined by HPLC and the blood glucose, lipid and dielectric were determined by automatic biochemistry instrument. Datas obtained were analyzed by DAS 2.0 and SPSS 13.0 software. RESULTS There were significant differences in pharmacokinetics parameters of Ke, MRT, t_1/2 and Cl comparing the rapid ascent group and the adaptation group with the plain group, and in that of t_1/2 and V comparing the adaptation group with the rapid ascent group. The blood glucose, and lipid were higher and the APOA and APOB were lower in the adaptation group than the rapid ascent group and plain group (P<0.01). The K were significant raised up in the rapid ascent group comparing with the plain group (P<0.05). There was significant difference between the adaptation group and the rapid ascent group in Cl and Ca contents. The P contents was stepped down in the rapid ascent group and the adaptation group. There were the positive correlation between TCH, GLU and t1/2(P<0.05 or 0.01) and the negative correlation between APOA and t_1/2, Vz/F(P<0.01) and between Cl and Vz/F (P<0.05). K, Ca were the positive correlation with AUC (P<0.05 or 0.01) and the negative correlation with Clz/F and Vz/F(P<0.05 or 0.01). CONCLUSION The blood glucose, lipid and dielectric have significant effects on AUC, t_1/2, Cl and Vz/F of pharmacokinetics of SMZ at high altitude.