Studies on Preparation and Dissolution Mechanism in Vitro of Ergoloid Mesylates Divided Dose Tablet of Extended-Release Microcapsule

OBJECTIVE To study prescription of ergoloid mesylates divided dose tablet of extended-release microcapsule (EDDTEM) and inspect dissolution mechanism in vitro. METHODS Ergoloid mesylates extended-release microcapsule (EEM) were prepared with alginate-chitosan as capsule wall material. The orthogonal experiment was designed to screen prescription. RESULTS The optimization of prescription was as follows: the proportion of alginate to drug is 6∶1, the proportion of alginate to chitosan is 4∶1, the concentration of alginate is 2.5%. The release behavior of EDDTEM was coincident with Higuchi equation. The dissolution mechanism were both diffusion and corrosion. CONCLUSION EDDTEM had good effect of extended-release in vitro and the release behavior in vivo needs to be inspected.