Applying Grading Methods of Synthesizing Multiple Guidelines to Optimize Extraction Technology for Shujintongluo Granules

OBJECTIVE To investigate the technology of optimal extraction for Shujintongluo granules. METHODS Based on the function and indication of the formula and the properties of its chemical components, orthogonal design was employed for conducting the multiple guidelines evaluation and selecting the optimum extraction technology with paeoniflorin, total alkaloids and the yield of extraction as the detective index. RESULTS The optimal extraction technology of Shujintongluo granules was by 8 times volume of water soaking for 1.5 h, then extracting 3 times with 1.5 h for each time. CONCLUSION The optimized extraction condition is reasonable and scientific, and it could be used in future large-scaled preparation of Shujintongluo granules.