Synthesis of Nimorazole

YU Shuhai, YANG Jianhui, ZHANG Zhiwei. Synthesis of Nimorazole[J]. Chinese Journal of Modern Applied Pharmacy, 2010, 27(3): 226-227.

Citation:

YU Shuhai, YANG Jianhui, ZHANG Zhiwei. Synthesis of Nimorazole[J]. Chinese Journal of Modern Applied Pharmacy, 2010, 27(3): 226-227.

Citation:

YU Shuhai, YANG Jianhui, ZHANG Zhiwei. Synthesis of Nimorazole[J]. Chinese Journal of Modern Applied Pharmacy, 2010, 27(3): 226-227.

Abstract

OBJECTIVE To synthesis nimorazole. METHODS Nimorazole was prepared by reaction of morpholine with 2-chloroethanol, via chlorination, and condensed with 4(5)-nitro-imidazole in the presence of phase-transfer catalyst. RESULTS The structure was identified by mp., IR and 1H-NMR. CONCLUSION The process can be easily controlled and suitable for a scale production.

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