Synthesis of Coumarin-7-sulfonylurea and Study on its Hypoglycemic Activity

OBJECTIVE To search some new compounds which have hypoglycemic activities. METHODS Novel coumarin-7-sulfonylurea compounds were designed and synthesized by combining the active moieties of hypoglycemic drugs. Their hypoglycemic activities were evaluated in mice. RESULTS These 6 targeted compounds were synthesized and characterized by FT-IR, 1H-NMR and MS spectra. CONCLUSION The preliminary results showed that MSU-3 exhibited evident hypoglycemic effect (P<0.01, CMC-Na as negative control) at the dose of 50 mg·kg^-1, suggesting the promising potential for further investigation.