Effect of Large Doses Hemocoagulase Agkistrodon Acutus on the Plasma Fibrinogen Level in Rabbits

OBJECTIVE To study the effect of large doses hemocoagulase Agkistrodon acutus on the fibrinogen level in rabbit, to provide a reference for clinical application. METHODS The 30 rabbits were randomly divided into 5 groups and were injected with different doses of hemocoagulase Agkistrodon acutus respectively, the plasma fibrinogen level were examined after administration. RESULTS The hemocoagulase Agkistrodon acutus with 0.2-1.0 U·kg^-1 doses resulted in the significant decrease of the plasma fibrinogen level of rabbits. The depletion of plasma fibrinogen was first occurred in individual rabbit at 0.4 U·kg^-1 doses, and while the doses were increased above 0.6 U·kg^-1(include 0.6 U·kg^-1). The depletion of plasma fibrinogen was occurred in all rabbits. CONCLUSIONS The large doses hemocoagulase Agkistrodon acutus have significant effects of decreasing the plasma fibrinogen level of rabbits.