Improved Synthesis Process of Cefathiamidine

OBJECTIVE To synthesize the title compound and improve process to make it suitable for industrial production, and increase yield. METHODS Cefathiamidine was synthesized from 7-ACA as starting material, acylated by bromoacetyl bromide at C-7 position in a low temperature and alkaline condition, and then condensed by side chain diisopropylthiourea. RESULTS The overall yield was increased from 45% to 62%, the structure of product was confirmed by IR, MS, and 1H-NMR. CONCLUSION The improved process was greatly simplified, with a total yield improved, and suitable for industrial production.