Study of Slug Capsule on Teratogenicity and Mutagenicity

OBJECTIVE To explore the toxicological effects of Slug capsule on teratogenicity and mutagenicity. METHODS Effects of Slug capsule on teratogenicity and mutagenicity weretested by teratogenesis in rats, Ames assay, Amblem nuclear test in bone marrow cells of mice and chromosome aberration (CA) analysis in vitro.RESULTS The development toxicity was not observed in the development of embryos after treatment of Slug capsule. Compared with the control group, Slug capsules have no significant effect on mutagenesis to TA98, TA100 with or without S9 (P>0.05).The rate of CA in mice induced by Slug capsules had no significant difference compared with the control group (P>0.05).Slug capsules had no effect on the cultural mammal somatic chromosome.CONCLUSION Slug capsules had no effects of teratogenicity and chromosome damage, and indicated its clinical application was to be safe.