Formula and in Vitro Release Study of Norfloxacin Intra-gastric Floating Sustained Release Tablets

OBJECTIVE Norfloxacin intra-gastric floating sustained-release tablets were formulated and the in vitro release was studied. METHODS The in vitro release was determined and the effects of formulation factors were investigated. The data were analyzed by the statistical method-similar factor method. RESULTS The specification of HPMC affected significantly the sustained-release and continual floating property. The tablets showed a good sustained-release and continual floating property with HPMC K100M 120 mg tablet-1, sodium bicarbonate 200 mg·tablet-1, CMS-Na 100 mg·tablet-1. CONCLUSION The tablets showed a good sustained-release and continual floating property with the formula.