Pharmacokinetic Study of Huangyangning Sustained-Release Capsules in Dogs

OBJECTIVE To investigate the pharmacokinetic of Huangyangning sustained-release capsules in dogs. METHODS Two groups of Beagle dogs were dosed with 6 mg Huangyangning sustained-release capsules or Huangyangning tablets via orally administration, and two groups were treated alternatively after two weeks. The blood drug concentrations were determined by HPLC to estimate the pharmacokinetic parameters and the relative bioavailability. RESULTS The Cmax values of Huangyangning sustained-release capsules and Huangyangning tablets were (5.28±0.81) ng·mL-1 and (11.70±2.01)ng·mL-1, the tmax values were (4.3±0.5) h and (1.0±0.1) h, respectively. The relative bioavailability of sustained-release capsules was 96.23%. CONCLUSION Huangyangning sustained-release capsules have significantly characteristic of sustained-release.