Preparation of Galantamine Hydrobromide Orally Disintegrating Tablets

OBJECTIVE To investigate the composition and process of galantamine hydrobromide orally disintegrating tablets(ODT). METHODS Effect of primary excipients on in vitro disintegration time of galantamine hydrobromide ODT was studied, the optimal formulation was selected based on the disintegrate time and the dissolution test was carried out. RESULTS The final galantamine hydrobromide ODT comprised MCC and PVPP with aweight ratio of 2∶3 as disintegrate and mannitol as diluents. The disintegration time was less than 30 s and the hardness was 30-50 N. The dissolution study inicated that above 90% of galantamine hydrobromide was released in 10 min. CONCLUSION The galantamine hydrobromide ODT is easy prepared and meet all the criteria of ODT. The disintegration and dissolution in oral was rapid with acceptable taste.