Preparation of Andrographolide Solid Dispersion Systems and Their Dissolution Test in Vitro

OBJECTIVE Solid dispersion technique was used for enhancing the dissolution rate of Andrographolide (Andro). METHODS Andro PVP solid dispersions which contain different proportion Tween-80 were prepared by solvent method. The composing of solid dispersion was optimized using orthogonal design. The dissolution rate in vitro was studied in artificial gastric juice. Powder X-ray diffraction (XRD) and Scanning electron micrograph (SEM) were used to analyze the characteristics of Andrographolide in solid dispersions. RESULTS Andro release from solid dispersions was significantly increased and its dissolution rate was raised when the higher content of Tween-80 was used. It was demonstrated that drug in Andro solid dispersion was an amorphous form by XRD and SEM. CONCLUSION Andro solid dispersion and surfactant Tween-80 can obviously increase Andro dissolution rate.