Adverse Effect and Mechanism of Chlorogenic Acid in Clearing Heat and Detoxication Traditional Chinese Medicine Injections

OBJECTIVE To discuss the adverse effect and mechanism of chlorogenic acid in three clearing heat and detoxication traditional Chinese medicine injections.METHODS Adverse effect and mechanism of chlorogenic acid were reviewed by collecting and summarizing the related reports in China and abroad.RESULTS All the three kinds of Chinese medicine injections contain chlorogenic acid, but there are different points of view on whether chlorogenic acid is the original sensitizer and whether it causes allergic reaction or anaphylactoid reactiona.CONCLUSION It is important to evaluate adverse effect of chlorogenic acid in traditional Chinese medicine injections and distinguish the allergic reaction and anaphylactoid reaction.